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For Shared Hosting customers the settings are as follows :

Protocol : POP3 or IMAP
Incoming Mail Server : mail.yourdomain.name
Outgoing Mail Server : mail.yourdomain.name
Account/Username : [email protected]
Password : [You're on your own here]
Advanced Settings :
Outgoing Authentication : ON (Login using same settings as incoming server)
Outgoing (SMTP) Port : 587

For VPS Customers its the same as the above, however you need to login as the VPS administrator and navigate to the following page :

Server -> Mail

On this page ensure that "Enable Message Submission" is ENABLED.